Muckle-Wells syndrome (MWS) is a rare autosomal dominant autoinflammatory disorder within the cryopyrin-associated periodic syndromes (CAPS) spectrum, caused by NLRP3 gene mutations leading to excessive IL-1β production. It presents with recurrent fever, urticarial rash, joint pain, sensorineural hearing loss, and risk of amyloidosis (AA amyloidosis leading to renal failure). Treatment...