What is Adrenocorticotropic Hormone (ACTH)? Adrenocorticotropic hormone (ACTH) is a polypeptide hormone produced and secreted by the anterior pituitary gland, located at the base of the brain. It plays a critical role in regulating the adrenal glands' production of cortisol, a key stress hormone involved in metabolism, immune response, and inflammation control. Therapeutically, ACTH is used to...