PORCN inhibitors are small-molecule drugs targeting the Porcupine (PORCN) enzyme, a key component of the Wnt signaling pathway. The Wnt pathway regulates cell proliferation, differentiation, and survival, and its aberrant activation drives oncogenesis in cancers like colorectal (30–40% Wnt-activated), pancreatic, and breast cancers. PORCN palmitoylates Wnt ligands, enabling their...